Showing posts with label glyconutrients. Show all posts
Showing posts with label glyconutrients. Show all posts

Monday, February 21, 2011

This, that and the other

We've got a lot going on with both boys right now, since doing our last stool tests and changing the course of treatments.  Well, not changing per say, but adding to them.  In the process, I have seen die-off in both boys, always a good sign, but not always fun to live through.

Full moon
Since the full moon was February 18th (three days ago), we started Gavin's parasite cleanse on the 14th (four days before the full moon).  The theory behind this is that parasites hatch during a full moon and in order to attack all stages of their life cycle, you start four days before a full moon and continue the cleanse until four days before the next full moon.  This time, in addition to the Humaworm kid's cleanse, I decided to add in the Artmesia and a worm cleanse called W-W by Pure Herbs.  I joined him in that cleanse, just for the heck of it, even though I plan to do the family cleanse again in April.  I am not doing Humaworm, just the W-W, Artmesia and I am adding in a separate black walnut hull capsule.  I have a feeling I have a parasite issue for sure, so it can't hurt to join him in the fun.  Since starting that cleanse with him, we've had a whole slew of die-off symptoms.  Whenever he goes through severe die-off, he experiences a day or two of minimal talking.  His speech always seems to suffer on the worst days.  I'm not sure, if it's the quality of his speech or if it's his mood which makes him less interested in being social or reasonable, and just becomes quiet and demanding at the same time.  There is definitely a mood that follows his die-off, one of anger, frustration and impatience, plus he clings to me while whining most of the day.  It's like nothing can make him happy, he wants something, then he doesn't want it, then he wants it again.  The screaming over it all is the most frustrating part about it, for us parents.  It's extremely exhausting, to say the least.  Other symptoms we have seen with this particular cleanse are: severe sleep disturbances which involve an inability for him to fall asleep and stay asleep, he wakes crying every 45 minutes until he is able to get into a deep sleep, he's craving sugars, he was irritable in the first few days, and his bloating looked incredibly painful, because it started very high in the abdomen and was so tight that blue veins were pressed visibly against his skin.  Six days into the cleanse, he had watery diarrhea that burned his rear so badly it left painful welts all the way down his thighs.  He couldn't even bear the feeling of his clean diaper against his skin at bedtime.  On this same day, his urine smelled horrible, almost like he had a bowl movement in his diaper, even though he drinks TONS of water.  There was definitely some form of potent toxin in his urine! He has had a problem with sweating for a few months now, sweating while napping or sleeping at night and now is no exception.  He wakes with his pillow soaked behind him.  Since doing research on parasite infection, this is a red flag for parasites!  Chelation was supposed to start coincidentally ON the full moon, so we decided to avoid this round with him so as not to tax his liver too much.

Glyconutrients update
On a good note, we have been able to add the glyconutrients back in without a rash.  We started back on them with half a teaspoon dose.  It's been well over a week now and no rashes so far!  I think last time perhaps we increased his dose too fast for his body to handle, because when we had gotten to a teaspoon and a half, we noticed the rash during a round of chelation, which means, there was probably too much detox between the glycos and chelation, together.  I would also imagine that the combination of the glyconutrients, the active parasite infection and chelation was just too much for his little liver.  Rashes are often a sign that the liver is malfunctioning.

For me, the parasite cleanse resulted in significant joint pain in my left wrist. This only happened on the day of the full moon and it was really painful.  The aches would come and go, throbbing deep in the joint.  One of my ankles felt like it hurt a little too, but it didn't last as long as the wrist hurt all day.  I experienced some itching (yes, rectal, nice huh?) and today after my second dose, I have a strange tightness in my chest that doesn't resolve with coughing.  I have also experienced alternating bowel movements like Gavin too.

Thyroid and iodine
My hair test suggested possible thyroid problems, so I am experimenting with Lugol's 2% iodine daily and since doing a patch test, I am increasing the dose.  I noticed that increasing the dose makes me feel better.  When you do an iodine patch test, the patch of brown iodine on your skin should remain there for 24 hours, if you aren't deficient.  If it disappears sooner, you are deficient.  My patch was gone in less than 9 hours!  So I will continue to increase the drops until the water tastes metalic to me, then I will back off and maintain at that dose.  Then I can repeat the patch test to see, if that dose is offering enough iodine to make my body happy.  When that happens, the patch should remain on my skin for at least 24 hours.  I am now also testing the boys with the patch test, today in fact!  Iodine is known to help with parasites, fungus and bacterial infections, so it's very possible they are deficient too.  I would guess that I could have passed on any of my own deficiencies to them, resulting in many of the issues we are battling now.

UPDATE - Within 5 hours, Gavin's iodine patch is gone!  I'd say he's deficient.  Grayson's is still going strong.  I guess tomorrow I will add iodine for Gavin and see how it changes things.  One thing I have learned in the interim is that adding iodine addresses parasites....interesting.

Attack of the antivirals
With Grayson, we decided to hit him hard with the natural antivirals and there is clearly a reaction happening.  I'm not sure, if the term die-off is appropriate in this situation, but it sure appears that way.  He was already taking high doses of olive leaf extract, and we added in monolaurin and lysine.  With the addition of these supplements, he is rubbing his face, nose and ears all day.  It doesn't seem to be bothering him.  He used to have more of a swatting action, but lately, it's a backhand rub on the cheeks, nose, across the mouth and forehead and he rubs the back of his head behind his ears a lot, sometimes grabbing and bending his ears.  He looks so funny when he has this chronic itching, because his hair is always sticking up all over from rubbing his head!  hahaha  In the past I would have thought this was a tic, but it's not a consistent motion (not sure, if that even matters) and he says he is itchy.  He is even putting the palm of his hand over his ear and pressing/rubbing, like you would if you had a deep inner ear itch. I've noticed that since I increased the monolaurin, he is now nasally too.  His tolerance of the monolaurin is low, we just increased his dose to three little pellets, when normally a scoop is used.  I am wondering, if this means he has a problem with Rubella, since I have heard that monolaurin is the natural antiviral of choice for rubella infections.  Oddly, even with these strange behaviors, his mood has been phenomonal!  In the very beginning, his moods were like the wind, but that passed quickly.  We've even increased his DMSA this round with no ill effects, amazingly!  In the past, just a tiny increase would send him into meltdown misery!  Not this time.  He's finally on a full 5mg dose of DMSA.  Still nowhere near his maximum dose since he could go as high as 20mg per dose safely!  I still feel like we are really making progress.  His more consistent cooperative moods make parenting a breeze!  This is something I haven't been able to say in years.  I am proud to say that I am enjoying these days immensely!

Sunday, January 23, 2011

Stressing...

We ordered DNA microbiology stool tests for both boys and decided to stop their nutraceuticals Saturday night, after the noon dose, then test mid-day Sunday.  This would give us about 20-24 hours without anything.  Well, it's now Sunday night and Gavin went in his diaper twice during sleep (before waking this morning and again at nap time) so they weren't sample worthy because of the diaper chemicals and Grayson hasn't had to go yet!

I am worrying about the length of time they are going without their nutraceuticals, more for Grayson than Gavin, because of school tomorrow.  I will have to keep him home from school to do this for two reasons.  One is that they give him a dose of his nutraceuticals during school, following a doctor's note.  And the other reason is because I don't want to set him up for failure, if things come to a head during the day.  So far both are doing surprisingly well, but we have experienced the calm before the storm in the past when my husband didn't give them any of their nutraceuticals all weekend while I was away, to see how they would do.  They were great all weekend, things came to a head days later and it was an absolutely horrible time that I would rather not repeat.  It took much longer than a few days to get them back to where they were.  It caused us to have to skip rounds of chelation and my life was incredibly difficult having two going through it at the same time.

One thing I can be sure of is that they will have their nutraceuticals out of their systems for sure.  Mommy might not fair so well over the next couple of days or weeks though.  Wish us luck....

Monday morning update - I had to keep Grayson home from school.  I was hoping they would both go by now so I could get them back on their nutraceuticals and glyconutrients (I stopped those too, since they can effect microbiology).  STILL no BMs in this house, ugh!  I can't believe this, they have both always been SO regular, I could practically set a clock by them and now, the ONE time I need them to go, they don't, neither of them.  I am praying that yeast overgrowth isn't causing some sort of constipation.  That would be quite the double-edged sword!  This morning we have a lot of hyperactivity, aggravation, impatience, and outbursts.  Grayson is doing a little better than Gavin.  Gavin is back to yelling about everything, he can't communicate without screaming and explosive outbursts. 

**OH, as I am writing this, Grayson has to go, YEAY!!  Off to collect a sample, woooo hooo!

Monday evening update - I was finally able to collect a sample from Gavin at about 1:30 today, thank goodness, because all of his old symptoms were back full force: the yelling, explosive outbursts, defiance, crying a lot, red anal ring, and he even had dark circles under his eyes.  Then tonight after a shower, I noticed that the wet dog smell that had been gone, came back slightly. I am convinced now that this was related to pathogen overgrowth. 

I decided to give both boys just half of their usual nutraceutical dose instead of bombarding their body with too much die-off at once.  This proved to be a good idea, because now at 6:30 pm, they are both doing GREAT!  I feel like Grayson didn't even skip a beat with this whole thing, which proves that chelation is really helping him.  Gavin is also back to a fairly level mood again too.  I reintroduced their glyconutrients today too and with that comes the happy faces. For Gavin, the glyconutrients has reinstated lots of thorough speaking.  His speech has most definitely been effected by the glyconutrients!  If this break has proven anything to me, it's that one thing!

Another thing I was able to decipher from this is that the rash Gavin got after starting the glyconutrients is not an intolerance/allergic reaction, because while he was off of them, it didn't change at all.  It had already been slowly drying up before stopping the glyconutrients and it is still in that same condition even after two days without them.  In the past, removing the source of his eczema made almost immediate changes in the rashes, within 24 hours at minimum.  I am convinced that the glyconutrients triggered a detox of some sort, whether it be viral, bacterial, yeast related, or even heavy metal or some other toxin. 

So hopefully we are back to "normal" and in a few weeks we will know what was going on for both of them this weekend when the tests results are in.  I can't wait!!!

Just a few little tidbits on yeast and mercury in honor of stool testing
For those of us going through chelation, we know all too well that yeast is a common complication of mercury.  Our daily attempts to maintain yeast levels is just a management process in place until we can bring mercury levels down with chelation.  It isn't the fix.  For those who are treating yeast regularly and not doing chelation, it's just a bandaid.

These little snippits of information are from Andy Cutlers's book "Amalgam Illness"
  • Intestinal overgrowth of yeast is common and often goes along with mercury poisoning.
  • Intestinal yeast overgrowth can crowd out the bacteria that produce vitamin K, which is essential for blood clotting.
  • Excessive yeast can also interfere with vitamin D metabolism in the liver and kidneys, affecting calcium metabolism.
  • One very direct test for yeast infection is to administer Nystatin, which kills yeast and see if you react to it (I would recommend GSE which is a natural yeast killer).  If yeast is causing a problem, killing it will exacerbate this problem.  Whatever symptoms flare up when enough yeast are killed are due to the yeast.  If no symptom flareup occurs, then intestinal yeast is present at an appropriate level.
  • A low sulfur diet may suppress yeast, a high sulfur diet will feed it as well as one high in sugars and carbohydrates.
  • Coffee is a sulfur food, tea has yeast killing tannin.  If you have a yeast problem, take your liquid stimulant in the form of strong black tea instead of coffee.
  • Repeated reappearance of skin dryness, hyperkeratosis or other irritation over areas where mercury containing antiseptics have been applied in the previous few years is not uncommon and should not be confused with yeast or fungal reinfection.

Thursday, January 20, 2011

Glyconutrients, how's it going?

Tomorrow will be ten days since we started the glyconutrients.  We have been on our therapeutic doses for six of those days. 

Glyconutrients + chelation = rapid detox?
We have also done a chelation round during the first week.  Chelation always sets things off for a few days and this was no exception.  Just about all of the gains we saw, especially in Gavin, were lost during the round.  I would expect that mobilizing metals would have this effect and in fact, if it's true that glyconutrients also enhance detox, I would expect the side effects of chelation to be even worse.  We managed through the round as usual though, just a bit rough here and there.  Grayson was emotional for a short period and then came off of the round like a champ!  Almost NO post round irritation AT ALL!  And the most amazing thing, his tummy was flat starting the last day of chelation and has continued for an entire 4 days straight!  Last night he was slightly bloated just as he went to bed, not exactly sure why, but he was flat again this morning.  Before last night though, the bloating literally did not come back even once during those three days and chelation ALWAYS makes him bloat more!  This was a pleasant surprise and the only thing we did different with this round was use the glyconutrients.  We didn't even use his homeopathic constitutional remedy like we normally do.  He's been waking happy and staying happy, he is flexible, cooperative, playing nicely with his brother, we are just utterly impressed with him!  The morning of his last day on this round of chelation, I came downstairs to find Grayson reading so sweetly to Gavin.  He was asking Gavin to point to things, "Gavin where is the hammer?.....where is something you would use to climb up higher?" referring to a ladder.  Gavin was excitedly reciprocating.  It was so cute!  They waited for breakfast in the front room while reading books, no fighting, no irritation, no questions about where their breakfast is....wow!  Is this what normalcy looks like?  If so, yes please!!

TMI
Something else new that both boys experienced was one odd day of very green, sticky, stringy nasal mucus.  It was something I have never experienced with either of them.  I swear, it was like GLUE!  Eeeeeeeeew!  Sorry for the details, but I found it interesting, especially since both got it on the same day and in both, it was gone the next day. 

Continued speech gains
We continue to see amazing gains in speech with Gavin daily.  He is adding new words to his vocabulary faster than I can even document.  He has always said "cake" for any form of bread and Saturday morning we were making pancakes, the first thing he said to us was, "I want pancakes!"  the entire word, PANCAKES!!  Then on Monday I made them bread and toasted some for breakfast, he promptly indicated that he wanted some "toast".  It's apparent to me that in addition to the added vocabulary, there is an increase in the cognition that comes with the use of these words.  Some might say this is just coincidental and that he was due for a developmental spurt in speech....I would vehemently disagree.  His speech has been slow since it started, this sudden rapid burst of speech occurred exactly when we added the glyconutrients, not a day sooner!  He is even adding slang into his sentences, for example, the other night he said to my husband, "Yeah, I want to see it..."  Yeah? Never heard him say that before either.  And he is suddenly saying, "See, Mommy?" as he turns something towards me to look at.  He is aware enough that he has to turn whatever it is he is referring to so that I can see it at the angle he was viewing it from originally!  Today my husband was working from home downstairs and I was making lunch for us.  I asked Gavin if he wanted to call him to come up for lunch.  I handed him the phone after dialing for him.  He waited for him to pick up at which point he said, "Hi Daddy, I eating, you come up eat." His father said that he was clear as day, he understood every word.  Then he said, "Bye Daddy" and hung up himself!  Oh, that is the other new thing...."ing".  He now uses "ing" to explain when he is doing something like, "I done eating".  Again, this is brand new to him, this week!

Detox or intolerance
One thing I am not sure how to address is a rash on Gavin.  It looks just like eczema he used to get, except that it isn't on his cheeks (yet anyway), it's on his bottom, towards the hip and around the back.  I have read that it's possible to get rashes on the glyconutrients and I know about detox rashes from doing chelation and treating Grayson for latent viruses, but there is something about giving a new supplement and seeing a rash that has me second guessing myself.  My first instinct was to stop giving whatever is causing it!  I read that with the glyconutrients, it's not uncommon to see a resurgence of symptoms in reverse from the order they were acquired.  So seeing the eczema would actually be in line with his personal healing.  The rash appeared during chelation too, which is interesting, because it's possible that the detox was kicked into high gear from the glyconutrients.  Of course, it's still possible that the rash is a reaction to an ingredient, so I am cautious, watching it's progression.  Today it actually looks like it's starting to dry up and it doesn't look any larger than it was the past two days.  I have my fingers crossed that this is a good sign.  I know when clearing a person of viruses, this is a very good sign....so here's to hoping!  Check back for more as we progress.

Friday, January 14, 2011

Glyconutrients - day four

Both boys are definitely different and some of the ways are so hard to explain or even put my finger on, it's just that their dispositions overall are more "here" and "connected".  Since neither of my children have been diagnosed with any form of ASD, I should be clear that they always appeared to be connected (well, most of the time, not always), so this increased connection is a testament to the fact that I didn't even realize how disconnected they could be!  Does that make sense?  We are still having some mood swings, but they aren't as frequent or as severe as before, in fact, with Gavin (our two year old), his change is unreal!!  I think he is more effected by the addition of the glyconutrients and I have changed nothing else about his daily routines.

Change is good!
Gavin's gains are ocurring at lightening speed, I just can't even begin to tell you how many times throughout the day my jaw is dropping.  I am overjoyed at the impressive improvements I see literally by the minute!!

Just about every morning, Gavin would wake highly irritable, yelling for food, crying when it wasn't plopped in front of his face upon opening his sleepy eyes, very unreasonable overall.  He expressed his concerns with what appeared to be a lot of anxiety for such a little guy.  I always remember Grayson bopping around happily in ignorant bliss at this age, so I have been concerned about Gavin's inability to relax and enjoy his days home with mommy.  Since starting the glyconutrients, he is waking happy, staying happy and cooperating so much more than ever before!  That doesn't mean he doesn't have moments of irritation or tantrums when he doesn't get what he wants, after all he IS still two years old, but what IS different is how he recovers from the outburst and how he now seems to understand (and accept) my explanation of why he can't have/do what he wants, etc.  Here are just a few more examples of the progress I've taken note of in the first four days of taking glyconutrients, and the things I am listing below are things he has NEVER done before:

After his first dose (which was later in the day)
  • more alert and aware of family interactions, included himself in family conversations
  • humor at appropriate times
  • said sentences like, "I want read book", he has never used the verb "read" and book has always come out as "blook" in the past and he said "Mommy, I fall", his word for fall has ALWAYS been "go boom", even up until this afternoon, before the dose.
  • words are crisp and articulate and his annunciation is clear
After his second dose
  • started saying two-syllable words like uncover, button (t's were very clear) and snowsuit.
  • said "Grayson" during conversation, completely on his own, without prompting.
  • ate a big plate of raw cabbage and pepper as a snack without battling me for a more sweet snack.
  • ate brussel sprouts at dinner without negotiation or ultimatums.
After his third dose
  • said his first three-syllable word, clear as day, "cottonballs" (again, t's were crisp).
  • after his nap I saw a new personality emerging, he was silly and dancing, chit chatting with me.
  • SO much more patience with life in general, not anxious for no reason like before.
After his fourth dose
  • he put on his own socks without frustration (was proud of himself) and the second one was very challenging, he just kept trying, usually he would grunt and throw the sock if it didn't go on after the first attempt and most of the time, he didn't even want to try.
  • saying "please", "thank you" and "sorry" totally unprompted and at appropriate times, with feeling.
  • conversation is bouncing back and forth, in the past, I always felt like I was talking at him and he was only responding when he disagreed, we had mini conversations this morning, like a little adult.
  • he asked me to sit with him for breakfast, at the island, and proceeded to try to pull out the chair for me as he was asking me to sit with him.
  • NO ANXIETY while waiting for breakfast!!  Patiently asked, "I eat now, please?"
  • after going potty in his little potty seat he said, "I flush, Mommy." Flush is a word he has never used before.
  • taking direction without a battle.
  • playing on his own for longer periods of time.
  • singing and dancing during down-time instead of hanging from my robe.
Here he is glowing with happiness while playing outside yesterday!



With Grayson, the gains aren't nearly as numerous or quick, but both my husband and I have noticed that he is waking much more alert, less grumpy and tired.  He is also in much better spirits at dinner time with almost no irritation, unless something in particular sets him off.  We have always had problems with consistency with him, so only time will tell, it's too early still to know what kind of long-term effects this could have on him, but we DO see a change in his confidence and moods.  Two of which were his most deficient traits.  It's also harder to assess him, since he is in school most of the day, so I am looking forward to our first weekend together while on the glyconutrients, although, it will be interesting, because we will be on a chelation round too (#45!).  Oh, the excitement of our lives, lol.

With me, I have only noticed that I am not as tired as I should be, considering I have been waking up at 5:30 in the morning (do I suddenly need less sleep?) and not falling back asleep.  Nothing huge yet, but what could be happening is that the younger the person, the more quickly they respond to the supplementation.  This is only an assumption on my part, but it seems to be the trend here.

Our Dosing
We started the boys on half a teaspoon and I have been increasing a little bit each day.  They are both on one full teaspoon in the morning, as of today.  I've been advised to bring them up to a therapeutic dose of one and a half teaspoons.  After we see enough change in them to move them back to a maintenance dose (and they remain consistent) we should be able to take them down to anywhere from 1/4-1/2 teaspoon daily.  I look forward to making this pricey supplement stretch as far as possible, lol!

Glyconutrients seem to be a hot topic in the holistic health arena and I've gotten a lot of questions about where we bought ours, how it's working, and people just curious about glyconutrients' action in the body.  I would say this newly emerging supplement, could be a huge missing piece to our nation's big health crisis. Stay tuned....

Wednesday, January 12, 2011

Glyconutrient study results

I have gotten more questions about the glyconutrients so I thought I would post some study results here from various sites.  Please note that I am not suggesting or endorsing the use of glyconutrients, just sharing what I found in my own research on the topic.  It was this information coupled with the many testimonials I was able to find on websites and in forum discussions, that pushed us towards giving glyconutrients a try.

We definitely saw language gains with our two year old, literally following his first dose!

From the Arkansas Children's Nutrition Center - Effects of a Glyconutritional Supplement on Brain Potentials Associated with Language Processing.  

The effects of a nutritional supplement on language processing were studied in 20 healthy 20-30 year-old males.

Subjects were tested on two separate visits one week apart. On the first visit each subject received either supplement or placebo prior to testing. On the second visit subjects received the opposite
treatment. During testing, subjects judged (agree or disagree) whether a word following a sentence was related to the sentence. Brain potentials were recorded during testing, averaged separately for conditions, and analyzed using SPSS repeated measures software. Relative to placebo, the supplement was associated with decreased reaction time and a significant amplitude increase of the ERP slow-wave response in the agree condition. The slow-wave response has been related to post-stimulus processing,
i.e., preparation for the next stimulus and reflection on what has just transpired. These findings are consistent with a facilitatory effect of the nutritional supplement on information processing

The late-occurring Slow Wave did discriminate between treatment conditions,
showing a significant supplement-related amplitude increase in the Agree condition. This effect -- greatest at sites associated with executive functioning, alertness and emotion (i.e., frontally; Andreassi, 2000) -- has been related to post-decisional processing. These findings are consistent with a facilitatory effect of the nutritional supplement on aspects of performance and information processing.
It is important to note that the supplement did not have any side effects, and consequently these positive influences are not associated with other known supplement-related effects.
-Andreassi, J.L. (2000) Psychophysiology 4th edition, Lawrence Erlbaum Associates, Mahwah, NJ.



Oxidative stress has been an ongoing problem with children on the spectrum, so this study is particularly interesting.

Effect of Ambrotose AO® on resting and exercise-induced antioxidant capacity and oxidative stress in healthy adults

Richard J Bloomer , Robert E Canale , Megan M Blankenship and Kelsey H Fisher-Wellman
Cardiorespiratory/Metabolic Laboratory, The University of Memphis, Memphis, TN 38152, USA

Methods

25 individuals (7 trained and 5 untrained men; 7 trained and 6 untrained women) received Ambrotose AO® (4 capsules per day = 2 grams per day) or a placebo for 3 weeks in a random order, double blind cross-over design (with a 3 week washout period). Blood samples were collected at rest, and at 0 and 30 minutes following a graded exercise treadmill test (GXT) performed to exhaustion, both before and after each 3 week supplementation period. Samples were analyzed for Trolox Equivalent Antioxidant Capacity (TEAC), Oxygen Radical Absorbance Capacity (ORAC), malondialdehyde (MDA), hydrogen peroxide (H2O2), and nitrate/nitrite (NOx). Quality of life was assessed using the SF-12 form and exercise time to exhaustion was recorded. Resting blood samples were analyzed for complete blood count (CBC), metabolic panel, and lipid panel before and after each 3 week supplementation period. Dietary intake during the week before each exercise test was recorded.

Results

No condition effects were noted for SF-12 data, for GXT time to exhaustion, or for any variable within the CBC, metabolic panel, or lipid panel (p > 0.05). Treatment with Ambrotose AO® resulted in an increase in resting levels of TEAC (p = 0.02) and ORAC (p < 0.0001). No significant change was noted in resting levels of MDA, H2O2, or NOx (p > 0.05). Exercise resulted in an acute increase in TEAC, MDA, and H2O2 (p < 0.05), all which were higher at 0 minutes post exercise compared to pre exercise (p < 0.05). No condition effects were noted for exercise related data (p > 0.05), with the exception of ORAC (p = 0.0005) which was greater at 30 minutes post exercise for Ambrotose AO® compared to placebo.

Conclusion

Ambrotose AO® at a daily dosage of 4 capsules per day increases resting blood antioxidant capacity and may enhance post exercise antioxidant capacity. However, no statistically detected difference is observed in resting or exercise-induced oxidative stress biomarkers, in quality of life, or in GXT time to exhaustion.


How many children on the ASD have you heard of that are infected with the HHV-6 virus?  Read on...

Integr Physiol Behav Sci. 1998 Jul-Sep;33(3):280-7.

The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

University of California, Irvine, Department of Medicine, Orange 92668, USA.

Abstract

In humans, eight monosaccharides are required for the synthesis of glycoproteins. Dietary supplements that supply these crucial sugars are known as glyconutrients. A glyconutrient compound was added to Peripheral Blood Mononuclear Cells (PBMC) isolated from normal controls and patients with the Chronic Fatigue Syndrome (CFS), a disease associated with immune dysregulation. The in vitro immunomodulatory effects were investigated. Cell surface expression of the glycoproteins CD5, CD8, and CD11a were significantly lower in patients with CFS compared to normal controls. Addition of glyconutrient homogenate to PBMC from patients with CFS stimulated with phytohemagglutinin significantly increased the expression of each glycoprotein. Furthermore, natural killer (NK) cell function was reduced in CFS patients. The glyconutrient preparation significantly enhanced NK cell activity versus human herpes virus 6 (HHV-6)-infected H9 cells in an 8 h 51Cr release assay compared to placebo for PBMC from patients with CFS (p< .01). Finally, apoptosis was significantly higher in patients with CFS. The percentage of apoptotic cells was significantly decreased in PBMC from patients with CFS that had been incubated for 48 h with glyconutrients. Thus, glyconutrients improved abnormal immune parameters in vitro in patients with CFS.
PMID: 9829439 [PubMed - indexed for MEDLINE]



This one is big for me, because our kids fight daily pathogenic overgrowth due to immune system dysfunction, also from PubMed.
Int J Immunopharmacol. 2000 Apr;22(4):299-308.

Effects of a glyconutrient on macrophage functions.

Department of Biological Sciences, Texas Tech University, Lubbock, Texas 79409, USA.

Abstract

Previous studies have shown that mannosylated bovine serum albumin (mBSA) enhances the respiratory burst (RB), phagocytosis, and killing of Candida albicans and Escherichia coli by resident murine peritoneal macrophages (Mphi). Upregulation of the above Mphi functions was associated with the binding of mBSA to the macrophage mannose receptor. The present study was done to determine if certain glyconutrients could stimulate Mphi functions in a similar manner. Resident peritoneal murine Mphi collected from C57BL/6 mice were exposed to the glyconutrients for 10 and 60 min. The RB was measured using chemiluminescence. Both phagocytosis and killing were measured after incubation with each of the following microorganisms: Candida albicans, Escherichia coli and Staphylococcus aureus. The percent phagocytosis and killing were determined using fluorescence microscopy. Results indicated that certain glyconutrients, caused a dose and time dependent effect on Mphi-induced killing of all three microorganisms.
PMID: 10689103 [PubMed - indexed for MEDLINE]



Plant-derived nutraceutical may boost brain power
Glyconutrient supplementation may have effects on cognitive function, according to a study that examined the influence of these plant sugars on perception, cognition and memory in 62 college students. In randomized, double-blind, cross-over trial with 1-week wash out periods, participants received 1 tablespoon of glyconutrients or placebo (rice starch) 45 minutes before performing cognitive tasks designed to evaluate perceptual skills, attention, working memory, etc. The students' scores indicated significant improvement in accuracy of visual discrimination (of environmental inputs) following glyconutrient supplementation but not following placebo. In addition, scores on the simple, but not complex, working memory task were better after glyconutrient consumption than after placebo; although the difference was significant for only one of two sessions. Scores on tasks of cognition and attention were not significantly different between glyconutrient and placebo conditions.

Source: Stancil AN and Hicks LH.* Glyconutrients and perception, cognition, and memory. Percept Mot Skills. 2009;108: 259-270

* Both at Howard University, Washington, DC



Shirley's Wellness Cafe (where I go frequently for health info) has a number of listed glyconutrient cases here.

This is from Shirley's Wellness Cafe

C.E. Pippenger, PhD, the Peter C. and Pat Cook research professor in the department of biomedica/health sciences at Grand Valley State University in Allendale, Mich., has heard some anecdotal accounts from pediatric pulmonologists who have seen patients helped tremendously by glyconutrients (saccharides).  Their reports spurred him to conduct one of the country's few double-blind, phyto-controlled studies of nutritional supplements in children with asthma.
In his study, Dr. Pippenger followed 100 patients with asthma and their use of glyconutrients, phytonutrients and a combination of both starting in January 2001.  Ninety-two patients from the original group completed the study by June 2002.  Most patients who didn't complete the study left it due to compliance problems.  He expects results will be available sometime this fall.
"We began the study because we believe the science surrounding glycobiology and receptors and interrelationships between sugars, cell function and the immune system are justified," Dr. Pippenger said.  "If we can demonstrate that there's an effectiveness to nutritional supplements, then we can have a strong foundation for administering these to asthmatic children.  They may decrease the amount of other medications the children."
Sharon Riesen, MD, assistant professor of pediatrics at Loma Linda University, Loma Linda, Calif., also has been studying glyconutrients and their effects on children with asthma.  Preliminary results of her open-label, controlled crossover study who 60 percent to 70 percent of its participants who used glyconutrients reported improvement of their asthma symptoms.  Glyconutrients appeared safe, and no child involved in the study needed to stop due to side effects, "which is incredibly rare, even with the placebo," she said.
"My passion is to get this information out to physicians that they could be using glyconutrients instead of medicines like prednisone," Dr. Riesen said.  "The side effects of so many of the asthma medicines are intense.  To have the kind of success that glyconutrients appear to have with asthma without side effects and have the majority of physicians not know anything about it is a shame."


For yet another wonderful explanation of glyconutrients by a mainstream doctor of medicine, Dr. Reg McDaniel, click here.


ManaRelief provides glyconutrients to malnurished children and orphans around the world and they have been doing it for 11 years!  In fact, if you look at some of the pictures here, you will see children holding bottles of Mannatech glyconutrients that have been donated by the company.

Tuesday, January 11, 2011

Update on Glyconutrients - first dose

Ok, so I didn't think I would be providing an update quite so soon, but my husband and I are sitting here with our mouths open, unsure of what to do.  We are at a loss, so we are just laughing hysterically.  We keep glancing at each other in awe pretty much.

We gave both kids their first doses of the glyconutrients today and both have responded with such energy that we are dumb-struck!  I have never seen energy like this in either of them, ever!  Both are deleteriously happy and running back and forth chasing each other across the whole house.  This increase in energy isn't all we are seeing though.  There is also an increase in cognition that I didn't know was possible, meaning, I thought they were where they belonged cognitively, so this was surprising to both Dave and I.  Gavin's speech took a leap well beyond gradual.  Granted, he's been coming a long way in the past few weeks, but tonight it's been even different from this morning!  For instance, a word he has ALWAYS used for when things fall, is "boom".  This morning he threw his Taggie and it landed on the floor in his room, he told me it went "boom".  Later in the day, he went up to get it and when he came back downstairs, I said, "Oh I see you found Taggie." and again he said "Boom Taggie" letting me know it was the one on the floor in his room.  Then tonight, after his first dose of the glyconutrients, for the first time ever in his life, he used the correct word!  He had been running with Grayson and fell down.  He promptly ran over to me and said, "Mommy, I fall!" Dave and I couldn't believe our ears!  Then another sentence came spewing from his mouth, "I want read book."  Wow, he's also never used the word "read"!  At dinner he pointed to our rice and and said, "rice"!  I didn't even know he knew the word, and even more interesting, he pointed to my egg roll and said, "wheat....roll!"  He also correctly identified the colors red, orange and blue, again, something he has never done, not correctly and so confidently!

And Grayson, he was SO happy and talking SO much, almost too much!  But everything in his mind was creative and spewing out of his mouth so fast, I couldn't keep up!  After running like a nut case with Gavin, he got very hot (which is quite common for him, but he normally gets VERY upset about it).  Well this time, he came over wiping his face and neck, panting, he said, "I am SO hot!" He had a long sleeve shirt under his short sleeve shirt, as he was reaching for his sleeve, he started to say, "can....." and he trailed off.  He was going to ask me to help him, which is ALWAYS the first thing out of his mouth.  Instead, he removed both shirts without complaint, put the long sleeve shirt in the mud room hamper and came back with the short sleeve shirt.  Again habit reigned and by default he said, "I can't do this", but again, he stopped and continued on with reversing his inside out shirt, all on his own!  He's never turned a shirt inside out without severe frustration!  He put it back on and then proudly said, "I was going to ask you, but I caught myself" and then off he went, happily!  Normally this would have resulted in frustration and a tantrum while he fumbled through reversing the shirt, and probably would have ended in him throwing the shirt in anger.

Is all of this the result of a sugar high, so to speak, since their bodies are lacking these sugars?  Keep in mind, they aren't the same as sweeteners, they are a complex carbohydrate type of sugar, concentrated.  Were they so on cue, because of the adrenaline or did it have something to do with new connections being made?  Will this continue or was this totally coincidence?  Only time will tell.  One thing I know for sure, my kids were different tonight than they have EVER been, ever!  We enjoyed the moments immensely and I look forward to more of them.

The newest - Glyconutrients

I have randomly seen glyconutrients mentioned in forums and on web sites for healing immune dysfunction, but their price and the idea of adding yet another supplement to our daily routine appealed to me just about as much as swimming with sharks would appeal to me!  So I never really chose to read much about them.  Recently, they popped up again in one of the forums I frequent and whenever I see someone mention them, they always say that they would never be without them.  That appears to be the recurring feeling about glyconutrients.  It intrigued me enough (especially since having illness after illness run through our household all through the holidays) to check out what they really do. 

Let me just start by saying that I am a skeptic by nature and when something appears too good to be true, it probably is!  Glyconutrients fit into that box for me, but the more I read, the more miraculous stories I would find, one after another, after another, people with Lupus, CFS, diabetes, Lyme, amoebic infections, and even cancer all healing!  I even came across quite a few reports of success with autistic kids.  So I dug deeper into the function of the product and let me just say this, it makes sense. 

Let me try to provide you with a simple explanation about what glyconutrients are.  Glyconutrients are immune modulators.  Ok, so what exactly does that mean?  Our cells are surrounded by little hairs that hold carbohydrate sugars and these sugars are how our cells communicate to each other.  Simply put, if we don't have these sugars or we are even just short on them, our cells aren't communicating properly, and what happens when our cells don't communicate properly?  Well, they begin to misunderstand which cells are safe and which are intruders, AKA - autoimmune disease, our body begins to attack healthy cells, among other things.  When our cells can't determine which cells are safe and which are intruders, that also means that viruses, yeast, bacteria, parasites and the like, are free to roam our bodies where they will do a number on the immune system and organ function.  This is precisely how cancer starts!  We all have cancer cells in our bodies, but our own cells (when communicating properly) attack them, regularly.  These little battles occur in your body daily!  I am sure the next question on your lips is why wouldn't we have these sugars surrounding our cells?  Some of them we make in our bodies and some are obtained only from diet.  In order for our body to make the sugars that it can  and should be making, we need at least two of the sugars obtained from our diet.  Soils do not contain the nutrients it once did, so we are deficient in many nutrients, including these sugars.  And just to stop here for a moment, we NEED these sugars to survive, did you get that?  We cannot survive without them, that is how important they are! 

Another piece I find interesting is for those who are casein free, because one of the sugars known as galactose, is only available in milk.  When you remove milk from one's diet, they aren't getting these precious sugars anywhere else.  This would make sense why children on the GFCF diet would suffer from the results of a deficiency in these sugars!  I'm sure you are thinking, well, just put those sugars back into the diet then!  Not as easy as it appears.  The reason casein is removed in the first place, is the inability for these children to digest it, which means, they wouldn't benefit from the sugars if they were returned to the diet anyway.  So glyconutrients provide these necessary sugars to our starved cells. 

The most amazing piece of information I gathered from all of my research involves stem cells.  There was a study done where the doctor checked all the participants before dosing them with 6 days of glyconutrients, most of them had no stem cells to speak of.  Within a week of taking the glyconutrients, these same people showed an average of between 200-400 stem cells in one small sample of blood!  Multiply that by the entire body and that is TRILLIONS of stem cells!!  Do you know what this can mean?  What illness does not respond to stem cells?  The minute I read that, I was sold.

There have been multiple Nobel awards given for glycobiotics, doctors use and recommend their use, there are books written on the topic, so I figured what the heck, if they will do what the science says they will do, perhaps we can cut down on some of the other things we use.  I don't expect them to be THE answer, but to aid in a faster recovery, maybe!  Needless to say we decided to give them a shot, and heck, when the company offers a 90 day money back guarantee, how could I resist??  We chose to purchase from a company whose product only contains the top two important sugars known to effect healing, galactose and mannose.  Using other formulations reduces the concentrations of these very important sugars, thereby reducing their effectiveness, so the quality of the product is VERY important.  The other thing that was important to me about the product we chose is that they don't have multiple fillers.  They use a small amount of larch bark (not rice bran like other companies) to aid in mixing the product with liquid.  It is a completely pure product with no other extras, so when you spend your small fortune on a bottle of miracle sugars, you are sure you are getting pure sugars, no extras.  This also means that the bottle lasts longer, because the dose necessary to reach therapeutic results is much lower. 

Our delivery arrived today, I was like a school girl again, giddy with excitement to start our first dose.  So Gavin and I dove right in.  We had empty bellies (requires taking on an empty stomach) so I promptly mixed a cocktail for each of us, at the starting doses.  Well, I went a little higher, because I didn't read the instructions, he he he.  I based my dose on a discussion I had with a representative of the company, who recommended starting the kids off at 1/2 teaspoon once a day, given with an EFA.  So I just chose double that, lol.  Within 30 minutes of that dose, I started feeling fatigued.  My eyelids became heavy, my head started to feel full and then I got this sensation all over me, including in my head, like I had a sudden increase in blood flow, complete with full-body goosebumps.  WEIRD!!  An hour later, it's all calmed down, but it definitely did SOMETHING to me!  It isn't uncommon to see a die-off effect from taking glyconutrients initially, because by allowing the cells to communicate properly, the pathogens will be attacked.  It also encourages natural detox. 

I am going to be chronicling our events, anything different or new while we embark on this new adventure. 

Wish us luck!